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The following systematic reviews are available for the topic fluoride, systemic. Links to summaries of the systematic reviews are provided if available. These summaries are not developed by the ADA. In some cases, links are provided to the full-text copy of systematic reviews published in the Journal of the American Dental Association (JADA).

Fluoridated milk for preventing dental caries.
Yeung CA, Hitchings JL, Macfarlane TV, Threlfall AG, Tickle M, Glenny AM. Cochrane Database Syst Rev. 2005;(3): CD003876.

• Abstract
• DARE Summary

Fluoride supplements and fluorosis: a meta-analysis.
Ismail AI, Bandekar RR. Community Dent Oral Epidemiol 1999; 27(1): 48-56.

• Abstract
• DARE Summary
• NLH Summary

Systematic review of water fluoridation.
McDonagh MS, Whiting PF, Wilson PM, Sutton AJ, Chestnutt I, Cooper J, Misso K, Bradley M, Treasure E, Kleijnen J. BMJ 2000; 321(7265): 855-9.

• Abstract
• DARE Summary

Community water fluoridation and caries prevention: a critical review.
Pizzo G, Piscopo MR, Pizzo I, Giuliana G.  Clin Oral Investig 2007 Sep;11(3):189-93. 

• Abstract

Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis.
Vestergaard P, Jorgensen NR, Schwarz P, Mosekilde L. Osteoporos Int 2008;19(3):257-68.

• Abstract