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Updated: March 27, 2013

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Alzheimer’s Association:
“According to the best available scientific evidence, there is no relationship between silver dental fillings and Alzheimer’s. …Many scientists consider these studies compelling evidence that dental amalgam is not a major risk factor for Alzheimer’s disease”:

  1. March 1991, the Dental Devices Panel of the FDA concluded there was no current evidence that amalgam poses any danger
  2. National Institutes of Health (NIH) in 1991 funded a study at the University of Kentucky to investigate the relationship between amalgam fillings and Alzheimer's. Analysis by University statisticians revealed no significant association between silver fillings and Alzheimer's;
  3. October 30, 2003, a New England Journal of Medicine article concluded that current evidence shows no connection between mercury-containing dental fillings and Alzheimer's or other neurological diseases. The abstract for this study is posted on the New England Journal of Medicine Web site.


American Academy of Pediatrics:
“Although dental amalgams are a source of mercury exposure and are associated with slightly higher urinary mercury excretion, there is no scientific evidence of any measurable clinical toxic effects other than rare hypersensitivity reactions. An expert panel for the National Institutes of Health has concluded that existing evidence indicates dental amalgams do not pose a health risk and should not be replaced merely to decrease mercury exposure.”


Autism Society of America:
“There is no known single cause for autism, but it is generally accepted that it is caused by abnormalities in brain structure or function. Brain scans show differences in the shape and structure of the brain in children with autism versus neuro-typical children. Researchers are investigating a number of theories, including the link between heredity, genetics and medical problems. In many families, there appears to be a pattern of autism or related disabilities, further supporting a genetic basis to the disorder. While no one gene has been identified as causing autism, researchers are searching for irregular segments of genetic code that children with autism may have inherited. It also appears that some children are born with a susceptibility to autism, but researchers have not yet identified a single "trigger" that causes autism to develop.”


U.S. Environmental Protection Agency: 
“Since the 1990s, several federal agencies have reviewed the scientific literature looking for links between dental amalgam and health problems. According to the Centers for Disease Control and Prevention (CDC), there is little scientific evidence that the health of the vast majority of people with dental amalgam is compromised, nor that removing amalgam fillings has any beneficial effect on health.”


Mayo Clinic:
“Amalgam fillings are safe. A great deal of research has examined these fillings and found them to be an effective, long-lasting treatment for dental decay. Amalgam, or silver, fillings are made with mercury, silver, tin and copper. In some cases, other metals may be included in amalgam fillings, too. Amalgam has been used for many years to replace decayed areas within teeth. It's an excellent material for this purpose. Amalgam is a strong, stable substance that holds up well when placed in a moist environment. It's also a good choice because it can tolerate the dramatic changes in temperature within your mouth.”

Source: “Amalgam is a safe and durable choice for fillings” in Medical Edge from Mayo Clinic – January 28, 2013

Multiple Sclerosis Society:
“There is no scientific evidence to connect the development or worsening of MS with dental fillings containing mercury, and therefore no reason to have those fillings removed. Although poisoning with heavy metals-such as mercury, lead, or manganese-can damage the nervous system and produce symptoms such as tremor and weakness, the damage is inflicted in a different way than occurs in MS and the process is also different.”


“There have been claims over the years that mercury leaking from amalgam dental fillings damages the immune system and causes a broad range of diseases, including MS. While the cause of MS remains unknown, there is no scientific evidence that heavy metal poisoning is responsible for either the onset or worsening of MS. There is no reason to have your dental fillings removed or replaced. This is a very expensive procedure with no proven benefit for people with MS.”

Source: “Dental Health” brochure –

U.S. Food and Drug Administration:
“FDA has reviewed the best available scientific evidence to determine whether the low levels of mercury vapor associated with dental amalgam fillings are a cause for concern. Based on this evidence, FDA considers dental amalgam fillings safe for adults and children ages 6 and above. The amount of mercury measured in the bodies of people with dental amalgam fillings is well below levels associated with adverse health effects…FDA concludes that the existing data support a finding that infants are not at risk for adverse health effects from the breast milk of women exposed to mercury vapor from dental amalgam. The estimated daily dose of mercury vapor in children under age 6 with dental amalgams is also expected to be at or below levels that the EPA and CDC consider safe.”


New England Journal of Medicine:
“Current concern arises from claims that long-term exposure to low concentrations of mercury vapor from amalgams either causes or exacerbates degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease.  Speculation has been most intense with respect to Alzheimer’s disease after a report that the brains of patients with Alzheimer’s disease had elevated mercury concentrations. However, several epidemiological investigations failed to provide evidence of a role of amalgam in these degenerative diseases . . .. Patients who have questions about the potential relation between mercury and degenerative diseases can be assured that the available evidence shows no connection.”

Source:  New England Journal of Medicine 349; 18, October 30, 2003, pp. 1731-1737.

International Journal of Dentistry:
"According to the available articles and data reviewed in this paper, the following conclusions can be drawn: 1) Mercury released from dental amalgam restorations does not contribute to systemic disease or systemic toxicological effects, 2) Allergic reactions to mercury from dental amalgam restorations have been demonstrated, but these are extremely rare, and 3) Available scientific data do not justify the discontinuation of dental amalgam use from clinical practice or the replacement with other single-tooth restorative dental materials.”

Source: “Biocompatibility of Dental Amalgams” – November 2011 

Council Against Health Fraud: 
"The National Council Against Health Fraud believes that amalgam fillings are safe…" "There is no logical reason to worry about the safety of amalgam fillings."

Source: National Council Against Health Fraud Web site – 2002
The National Institute of Dental and Craniofacial Research (NIDCR – part of the National Institutes of Health):
“Both studies—one conducted in Europe, the other in the United States—independently reached the conclusion: Children whose cavities were filled with dental amalgam had no adverse health effects. The findings included no detectable loss of intelligence, memory, coordination, concentration, nerve conduction, or kidney function during the 5-7 years the children were followed.”

Source: Studies Evaluate Health Effects of Dental Amalgam Fillings in Children – 2006