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March JADA looks at phentolamine mesylate use after dental care

February 24, 2017

By Michelle Manchir

Image of March 2017 JADA coverPhentolamine mesylate is “well suited to reverse local anesthesia after routine dental procedures,” according to research published in the March issue of The Journal of the American Dental Association.

German researchers conducted two studies in patients receiving a local anesthetic as part of their dental treatment. They investigated the time to recovery of normal sensation and function and the frequency of adverse events in the patients who received phentolamine mesylate versus those who did not. Researchers found that the use of phentolamine mesylate “substantially reduced the time to recovery of normal sensation and functions after local anesthesia in routine dental treatment.”

The authors concluded that “the results confirm the effectiveness, safety and tolerability of phentolamine mesylate used in patients with routine dental conditions in Germany and that phentolamine mesylate augments the safety of dental treatments.”

To read the entire article, visit

Other highlights of March JADA include commentaries addressing recent ADA guidelines on sedation and general anesthesia by dentists; an article about rates and predictors of exposure to Legionella pneumophila in the U.S. among dental practitioners; and a case report about the management of cannabis-induced periodontitis via resective surgical therapy.

Every month, JADA articles are published online at in advance of the print publication.