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October JADA finds anti-inflammatory, analgesic drugs do not prevent bleaching sensitivity

September 24, 2019

By Mary Beth Versaci

Evidence suggests anti-inflammatory and analgesic drugs do not prevent tooth sensitivity caused by in-office dental bleaching, according to a systematic review published in the October issue of The Journal of the American Dental Association.

October JADA
In the cover story, "Effect of Anti-Inflammatory and Analgesic Drugs for the Prevention of Bleaching-Induced Tooth Sensitivity: A Systematic Review and Meta-Analysis," the authors examined 11 randomized clinical trials comparing anti-inflammatory and analgesic drugs with a placebo and evaluating tooth sensitivity after in-office bleaching.

The authors –– Dr. Márcia Luciana Carregosa Santana, Pollyana Caldeira Leal, Ph.D., Dr. Alessandra Reis and Dr. André Luis Faria-e-Silva –– found patients who took the drugs before having their teeth bleached experienced similar levels of sensitivity as those who did not take them.

"Despite the differences in drugs and protocols, the meta-analysis of the clinical trials evaluating the possible effect of anti-inflammatory and analgesic drugs for the prevention of bleaching-induced tooth sensitivity showed, with a high level of evidence, that these drugs did not prevent nor reduce tooth sensitivity," the authors said in the review.

To read the article, visit

Other articles in the October issue of JADA discuss longitudinal antibiotic-prescribing trends among U.S. dental specialists within a pharmacy benefits manager, filled dietary fluoride supplement prescriptions for Medicaid-enrolled children living in states with high and low water fluoridation coverage, and patients' knowledge and opinions regarding osteoporosis, osteoporosis treatment and dental care.

Every month, JADA articles are published online at in advance of the print publication.