ADASRI manuscript wins 2020 William J. Gies Award in clinical research

Photo of ADASRI staff
Best paper: A manuscript authored by the American Dental Association Science & Research Institute and Council on Scientific Affairs is the winner of this year's William J. Gies Award in clinical research. It was co-written by, from left, Dr. Alonso Carrasco-Labra, Ph.D., Olivia Urquhart, Malavika Tampi and Lauren Pilcher.
A manuscript authored by the American Dental Association Science & Research Institute and Council on Scientific Affairs won the 2020 William J. Gies Award in clinical research from the American and International Associations for Dental Research.

The associations would have presented the award, which includes a $1,000 honorarium, during the opening ceremony of their general session and exhibition March 18 in Washington, D.C., but the meeting was canceled because of the COVID-19 pandemic.

The Gies Award recognizes the best paper published in the Journal of Dental Research during the preceding year. "Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis" was first published online in October 2018 by the Journal of Dental Research and again in the international journal’s centennial issue in January 2019.

"The impact of this manuscript and its selection for this award cannot be overstated," said Dr. Mia Geisinger, chair of the Council on Scientific Affairs. "This is a worldwide award and helps showcase the ADA's strong commitment to science and discovery in the global oral health community."

The winning manuscript is the first network meta-analysis ever used to inform a clinical practice guideline in dentistry. It summarizes the evidence used to formulate the ADA's 2018 guideline on nonrestorative caries treatments.

Olivia Urquhart, a health research analyst who leads the ADA Clinical Evaluators Panel, was first author on the systematic review and network meta-analysis, and Dr. Rebecca Slayton, Ph.D., a professor at the University of Washington School of Dentistry, chaired the panel that wrote the systematic review and meta-analysis, as well as the associated guideline.

In addition to receiving the award, staff from the ADASRI were scheduled to present 30 abstracts at the canceled meeting. These abstracts will instead be published later this year in a special online-only issue of the Journal of Dental Research. All abstracts and some posters have also been made available via an online archive. The abstracts and presenters included:

• Methods for Incorporating Nonrandomized Study Data for Policy-making, presented by Lauren Pilcher, research assistant.

• EPR Properties of Carbonated Hydroxyapatite Synthesized through Calcium Phosphate Cements, presented by Eaman Karim, Ph.D., associate.

• Dental Light-Curing Unit Use — an ADA Clinical Evaluators Panel Survey, presented by Olivia Urquhart, health research analyst.

• Antibiotic Prescribing Habits and Preferences — a Survey of U.S. Dentists, presented by Rashad Vinh, scientific communication specialist.

• Determination of Available Fluoride and Antimicrobial Activity of Charcoal-Containing Dentifrices, presented by Christina Tyrakowski, Ph.D., senior analytical chemist.

• Physical and Thermal Behavior of "Clear" Plastic Orthodontic Materials, presented by Henry Lukic, engineering research associate.

• pH-Responsive Release of Chlorhexidine, presented by Xiaohong Wang, Ph.D., associate.

• A Fluoride-Calcium-Phosphate Treatment Produced Persistent Reduction in Dentin Hydraulic Conductance, presented by Laurence Chow, Ph.D., assistant director.

• The Mechanical and Physical Behavior of Dental Zirconia, presented by Spiro Megremis, Ph.D., research and laboratories director.

• GRADE Evidence-to-Decision Framework for Developing Oral Health Policy, presented by Malavika Tampi, manager of Center for Evidence-Based Dentistry.

• 3D Bioengineered Platform for Vascularized Bone Regeneration, presented by Eun-Jin Lee, Ph.D., associate.

• Stimuli-Responsive Azo-QPS-Containing Methacrylate Monomers/Polymers, presented by Han Byul Song, associate.

• Patients' Values and Preferences in Dentistry: Current State, Next Steps, presented by Sarah Pahlke, research assistant.

• Physicochemical, Mechanical, and Antimicrobial Evaluation of Novel Bioactive Resin, presented by Diane Bienek, Ph.D., research operations director.

• Policy and Guideline Development and Dissemination: The Role of Global Evidence Informing Local Policy and Clinical Decisions, presented by Dr. Alonso Carrasco-Labra, Ph.D., senior director.

• Development and Characterization of pH Sensors for Oral Cavity, presented by Nicole Ritzert, Ph.D., project leader.

• Oral Cancer Risk Factor, presented by Shinae Kim, Ph.D., project leader.

• Calcium Fluoride and Fluorapatite Formation in Fluoride-Calcium-Phosphate Complex Solutions, presented by Shozo Tagaki, Ph.D., senior project leader.

• Minimize Polymerization Stress Using a pH-Sensitive Compound, presented by Jirun Sun, Ph.D., senior project leader.

• Novel Antimicrobial Monomers Increase Shear Bond Strength of Dental Restoration, presented by Leopoldo Torres Jr., Ph.D., associate.

• Dentin Biomodification Induced by Proanthocyanidins from Rhodiola rosea, presented by Dr. Ariene Leme-Kraus, Ph.D., senior research associate.

• U.S. Trends in Antibiotic Prescription by Dentists, 2002–2017, presented by Cameron Estrich, Ph.D., health research analyst.

• Fracture-Toughness of Zirconia with Nanometer-Sized Notches Fabricated Using Focused-Ion-Beam Milling, presented by Yifeng Liao, Ph.D., manager of dental materials research.

• Study of 3Y-TZP Degradation via Accelerated Hydrothermal Aging, presented by Max Gruber, engineering research assistant.

• Development of Biofilm Model for Assessment of Oral Hygiene Products, presented by Erin Claussen, research assistant.

• Effectiveness of Cleanliness Quantification Methods at Evaluating Clinically Used Dental Instruments, presented by Prerna Gopal, Ph.D., manager of microbiology and chemistry.

• Protecting Pulp by Restoring Reparative Cellular Function in ECM Culture, presented by Gili Kaufman, Ph.D., project leader.

• Novel Bioactive Composite Materials for Dental and Bone Restorations, presented by Stanislav Frukhtbeyn, research associate.

• 3D Biomimetic Platform Reveals FOXO1/β-catenin Mechanism that Regulates Epithelial Barrier, presented by Styliani (Stella) Alimperti, Ph.D., project leader.

• 3D Bio-printed Platforms for Craniofacial and Dental Diseases, presented by Styliani (Stella) Alimperti, Ph.D., project leader.

In addition, Louis Erazo, senior clinical research associate, had been scheduled to host a breakfast breakthrough session titled "ADA Seal of Acceptance Program: An Introduction and Overview."