Recent publications from ADASRI

Read the latest research, conference abstracts, standards, and patents brought to you by the ADA Science & Research Institute, LLC.

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Recent publications by topic

Infection control

Employment Patterns of Dental Hygienists in the United States during the COVID-19 Pandemic: An Update (2022)
Study finds that fewer than half of dental hygienists who left employment early in the pandemic returned to the workforce in 2021. | By Rachel Morrissey, JoAnn Gurenlian, Cameron Estrich, Laura Eldridge, Ann Battrell, Ann Lynch, Mikkelsen Matthew, Brittany Harrison, Marcelo Araujo, and Marko Vujicic

Infection Prevention and Control Practices of Dental Hygienists in the United States during the COVID-19 Pandemic: A Longitudinal Study (2022)
Study finds almost all surveyed dental hygienists (99.9%) from September 2020 to August 2021 reported COVID-19-specific infection prevention and control practices in place at their primary dental clinic. | By Cameron Estrich, JoAnn Gurenlian, Ann Battrell, Ann Lynch, Matthew Mikkelsen, Rachel Morrissey, Marko Vujicic, and Marcelo Araujo

COVID-19 Vaccine Intention and Hesitancy of Dental Hygienists in the United States (2022)
Study finds that, as of August 2021, 75.4% of hygienists had been fully vaccinated against COVID-19, a higher proportion than the general public and health care workers overall outside dentistry at that time. | By JoAnn Gurenlian, Laura Eldridge, Cameron Estrich, Ann Battrell, Ann Lynch, Rachel Morrissey, Marcelo Araujo, Marko Vujicic, and Matthew Mikkelsen

Validating Cleanability of Dental Rotary Diamond Instruments Soiled with 2 Clinically Relevant Dental Test Soil Components (2022)
Study describes process that dental instrument makers can use to develop and validate cleaning instructions for their reusable instruments. | By Prerna Gopal, Erin Claussen, Kristy Azzolin, and Spiro Megremis

The "Oral" History of COVID-19: Primary Infection, Salivary Transmission, and Post-Acute Implications (2021)
A review summarizes the evidence of how SARS-CoV-2 infects the glands, oral mucosae, and saliva. | By Julie Teresa Marchesan, Blake M. Warner, and Kevin Byrd

COVID-19 among Dentists in the United States: A 6-Month Longitudinal Report of Accumulative Prevalence and Incidence (2021)
Survey determines the cumulative prevalence and incidence rates of COVID-19 among dentists and assesses their level of engagement in specific infection control practices. | By Marcelo Araujo, Cameron Estrich, Matthew Mikkelsen, Rachel Morrissey, Brittany Harrison, Maria Geisinger, Effie Ioannidou, and Marko Vujicic

SARS-CoV-2 Infection of the Oral Cavity and Saliva (2021)
Study shows how SARS-CoV-2 infects cells in mouth, possibly leading to oral symptoms. | By Kevin Byrd et al.

Responding to the COVID-19 Pandemic: The Mouth Is a Site of SARS-CoV-2 Infection (2021)
A team of investigators present the first direct evidence that SARS-CoV-2 can infect and replicate in the cells of the mouth in humans, and that saliva is potentially infectious. | By Blake Warner and Kevin Byrd

COVID-19 Prevalence and Related Practices among Dental Hygienists in the United States (2021)
Study estimates the prevalence of COVID-19 among US dental hygienists, describes infection prevention and control procedures, and identifies associated trends in mental health. | By Cameron Estrich, JoAnn Gurenlian, Ann Battrell, Sue Bessner, Ann Lynch, Matthew Mikkelsen, Rachel Morrissey, Marcelo Araujo, and Marko Vujicic

Long-Term Antibacterial Activity and Cytocompatibility of Novel Low-Shrinkage-Stress, Remineralizing Composites (2021)
New bioactive composite not only has a low shrinkage stress, but also down-regulates the growth of oral biofilms, reduces acid production, maintains antibacterial activity after 90-day aging, and does not compromise cytocompatibility. | By Ghalia Bhadila, Deepak Menon, Xiaohong Wang, Taissa Vila, Mary Ann Melo, Silvia Montaner, Dwayne Arola, Michael Weir, Jirun Sun, and Hockin Xu

AZO-Quaternary Pyridinium Salts with Acid-Enhanced Antibacterial Efficacy, Methods of Use, Methods of Synthesis, and Uses Thereof (2020)
A new azo-type quaternary pyridinium salt helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. | By Jirun Sun

Guidance on Method Development and Validation of Cleaning Processes of Dental Instruments (2020)
Technical report provides guidance on the development of cleaning processes for dental instruments, and their validation, as one of the steps in a multi-step instrument reprocessing procedure. | By the ADA Standards Committee on Dental Products

Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis (2020)
Study generates the first integrated human oral single cell RNA sequencing atlases to predict cellular sources of susceptibilities to SARS-CoV-2 infection. | By Kevin Byrd et al.

Estimating COVID-19 Prevalence and Infection Control Practices among Dentists (2020)
Researchers conduct the first longitudinal study designed to track COVID-19 infection control practices and infection rates among US dentists. | By Cameron G. Estrich, Matthew Mikkelsen, Rachel Morrissey, Maria Geisinger, Effie Ioannidou, Marko Vujicic, and Marcelo Araujo

Developing Cleaning Instructions for Reusable Dental Rotary Cutting Devices in the Context of a Risk Analysis in the USA (2020)
Risk analysis provides dental device manufacturers with information to better document cleaning procedures for their equipment. | By Kristy Azzolin

Effectiveness of Cleanliness Quantification Methods at Evaluating Clinically Used Dental Instruments (2020)
Study shows that a previously developed method, which was shown to be effective at detecting the cleanliness of artificially soiled dental instruments, was also effective at quantifying the cleanliness of clinically used dental instruments. | By Prerna Gopal, Erin Claussen, Satish Alapati, Mina Golubovich, Milica Novakovic, Jamie Spomer, and Spiro Megremis


Effect of Curcumin-Loaded Photoactivatable Polymeric Nanoparticle on Peri-implantitis-Related Biofilm (2022)
Curcumin-loaded polymeric nanoparticles have antimicrobial and antibiofilm properties, with better effects when associated with blue light, being a promising therapy for preventing and treating peri-implant diseases. | By Caroline Coradi Tonon, Beatriz Panariello, Marlus Chorilli, Denise Madalena Palomari Spolidorio, and Simone Duarte

Low-Temperature Plasma Short Exposure to Decontaminate Peri-Implantitis-Related Multispecies Biofilms on Titanium Surfaces In Vitro (2022)
Low-temperature plasma effectively reduces peri-implantitis-related multispecies biofilms on titanium surfaces in vitro. | By Beatriz Panariello, Drashty Mody, George Eckert, Lukasz Witek, Paulo Coelho, and Simone Duarte

Multifunctional Periodontal Probes and Their Handheld Electronic System for Simultaneous Temperature, pH, and Depth Measurements (2022)
Simultaneous measurement of temperature and pH along with gingival sulcus depth may detect early signs of inflammation that current methods, such as probing and radiography, may not identify, thus minimizing potential tissue damage caused by periodontal disease. | By Nicole Ritzert, Asha Rani, Taejun Ko, Jeffrey Kim, and Shinae Kim

The Chairside Periodontal Diagnostic Toolkit: Past, Present, and Future (2021)
Review provides an overview of the toolkit available for diagnosing periodontal diseases, discusses commercially available options, and highlights the need for collaborative research initiatives and technology to overcome the challenges of rapid periodontal disease diagnosis. | By Taejun Ko, Kevin Byrd, and Shinae Kim

Biofabrication of 3D Printed Hydroxyapatite Composite Scaffolds for Bone Regeneration (2021)
Proof-of-concept study opens venues in engineering high-resolution, implantable, and osteoconductive scaffolds with predetermined properties for bone regeneration. | By Yoontae Kim, Eun-Jin Lee, Albert Davydov, Stanislav Frukhtbeyen, Jonathan Seppala, Shozo Takagi, Laurence Chow, and Stella Alimperti

The "Gum–Gut" Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances (2021)
Review introduces the concept of the “gum–gut axis” as a framework for examining this reciprocal relationship between the periodontium and the gastrointestinal tract. | By Kevin Byrd and Ajay Gulati

An Oral-Mucosa-on-a-Chip Sensitively Evaluates Cell Responses to Dental Monomers (2021)
Findings suggest that the mucosa-chip is a promising alternative to traditional platforms or assays to test a variety of biomaterials by offering a multi-layered tissue geometry, accessible layer-specific information, and higher sensitivity in detecting cellular responses. | By Khanh Ly, S. Ali Rooholghodos, Christopher Rahimi, Benjamin Rahimi, Diane Bienek, Gili Kaufman, Christopher Raub, and Xiaolong Luo

Methods for Characterization of Bioactivity Using Confocal Microscopy (2020)
One common tissue engineering approach for regenerating or replacing damaged tissues involves a porous polymeric scaffold; this chapter discusses methods to evaluate cell distribution in the scaffolds using laser scanning confocal microscopy. | By Jirun Sun, Joy Dunkers, Sheng Lin-Gibson, and Nancy Lin

3D Bioengineered Platform for Vascularized Bone Regeneration (2020)
3D bicellular microphysiological models will be used as diagnostic tools for drug testing and identification of new targets involved in bone and craniofacial diseases. | By Eun-Jin Lee and Stella Alimperti

Development and Characterization of pH Sensors for Oral Cavity (2020)
Electrochemical pH sensors aid in detecting inflammation and/or disease of oral tissues. | By Nicole Ritzert, Shinae Kim, and Asha Rani

3D Biomimetic Platform Reveals FOXO1/β-catenin Mechanism that Regulates Epithelial Barrier (2020)
By Stella Alimperti, Matthew Staymates, Thomas Hart, and Dana Graves

3D Bio-printed Platforms for Craniofacial and Dental Diseases (2020)
Study captures dynamic changes on epithelial barriers under inflammatory conditions that could potentially provide therapeutic targets against periodontal diseases. | By Styliani Alimperti

Pharmacology and therapeutics

Evidence-based clinical practice guideline for the pharmacological management of acute dental pain in adolescents, adults, and older adults (2024)
Non-opioid medications are first-line therapy for managing acute dental pain following tooth extraction(s) and the temporary management of toothache in adolescents, adults and older adults. | By Alonso Carrasco-Labra, Deborah Polk, Olivia Rose Urquhart, Tara Aghaloo, J. William Claytor, Vineet Dhar, Raymond A. Dionne, Lorena Espinoza, Sharon Gordon, Elliot Hersh, Alan Law, Brian S.-K. Li, Paul J. Schwartz, Katie J. Suda, Michael A. Turturro, Marjorie Lindsay Wright, Tim Dawson, Anna Miroshnychenko, Sarah Pahlke, Lauren Pilcher, Michelle Shirey, Malavika Tampi, Paul A. Moore

Analgesics for the management of acute dental pain in the pediatric population: A systematic review and meta-analysis (2023)
A systematic review and meta-analysis of the literature on pharmacologic approaches to management of acute dental pain in children found that several over-the-counter medications used alone or in combination were seen to provide benefit. | By Anna Miroshnychenko, Maria Azab, Sara Ibrahim, Yetiani Roldan, Juan Pablo Diaz Martinez,Tamilselvan Tamilselvan, He Leon, Oliva Urquhart, Malavika Tampi, Deborah E. Polk, Paul A. Moore, Elliot V. Hersh, Alonso Carrasco-Labra, Romina Brignardello-Petersen.

Corticosteroids for managing acute pain subsequent to surgical extraction of mandibular third molars: A systematic review and meta-analysis (2023)
A systematic review and meta-analysis of the literature found trivial differences in postoperative pain when corticosteroids were administered orally, submucosally, or intramuscularly compared with a placebo in patients undergoing third-molar extractions.| By Anna Miroshnychenko, Maria Azab, Sara Ibrahim, Yetiani Roldan, Juan Pablo Diaz Martinez, Divyalakshmi Tamilselvan, Leon He, Olivia Urquhart, Francisca Verdugo-Paiva, Malavika Tampi, Deborah E. Polk, Paul A. Moore, Elliot V. Hersh, Romina Brignardello-Petersen, Alonso Carrasco-Labra

Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews (2023)
Systematic reviews of the literature evaluated effectiveness of local anesthetics on acute dental in patients after tooth extraction and in patients with symptomatic irreversible pulpitis found that bupivacaine may be superior to lidocaine with epinephrine and mepivacaine; and that benzocaine may be superior to placebo for short term (20-30 minutes) relief of pain. | By Anna Miroshnychenko, Sara Ibrahim, Maria Azab, Yetiani Roldan, Juan Pablo Diaz Martinez, Divyalakshmi Tamilselvan, Leon He, Olivia Urquhart, Malavika Tampi, Deborah E. Polk, Paul A. Moore, Elliott V. Hersh, Alonso Carrasco-Labra, and Romina Brignardello-Petersen.

Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis (2023)
A systematic review and network meta-analysis of risks and benefits of pharmacologic treatment for the management of acute postoperative pain following extraction of teeth in adults found that NSAIDs with or without acetaminophen result in better pain-related outcomes than opioids with or without acetaminophen (except acetaminophen 650 mg plus oxycodone 10 mg) or placebo. | By Anna Miroshnychenko, Sara Ibrahim, Maria Azab, Yetiani Roldan, Juan Pablo Diaz Martinez, Divyalakshmi Tamilselvan, Leon He, Joshua W. Little, Olivia Urquhart, Malavika Tampi, Paul A. Moore, Elliot V. Hersh, Bill Claytor, and Romina Brignardello-Petersen.

Patient values and preferences for managing acute dental pain elicited through online deliberation (2023)
Electronic surveys and small group engagement were used to elicit insight from study participants about relief of dental pain with respect with expected pain intensity. Although nonprescription and nonopioid pain relief options were preferred, willingness to accept opioid increased as expected pain levels increased, though mention of rescue analgesia as a third outcome could affect decision-making. | By Tim Dawson, Sarah Pahlke, Alonso Carrasco-Labra, and Deborah Polk.

Evidence-based clinical practice guideline for the pharmacological management of acute dental pain in children (2023)
Non-opioid medications, specifically NSAIDs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after tooth extraction(s) and the temporary management of toothache in children. | By Alonso Carrasco-Labra, Deborah E. Polk, Olivia Urquhart, Deborah E. Polk, Olivia Urquhart, Tara Aghaloo, J. William Claytor, Vineet Dhar, Raymond A. Dionne, Lorena Espinoza, Sharon M. Gordon, Elliot V. Hersh, Alan S. Law, Brian S.-K. Li, Paul J. Schwartz, Katie J. Suda, Michael A. Turturro, Marjorie Lindsay Wright, Tim Dawson, Anna Miroshnychenko, Sarah Pahlke, Lauren Pilcher, Michelle Shirey, Malavika Tampi, and Paul A. Moore.

Antibiotic Prescription Patterns among US General Dentists and Periodontists (2022)
A survey of dental practitioners and periodontists assesses factors that affect antibiotic prescribing practices among the two groups. | By Effie Ioannidou, Nico Geurs, Ruth Lipman, Marcelo Araujo, Jay Elkareh, Steven Engebretson, Robert Eber, Thomas Oates, Patricia Diaz, and Catherine Spino

Potentiometric Rotating Ring Disk Electrode Study of Interfacial pH during Carbon Dioxide Reduction and Hydrogen Generation in Neutral and Weakly Acidic Media (2022)
An analytical reaction–convection–diffusion model provides a useful platform for further exploration of electrode kinetics influenced by reaction-induced pH change. | By Brian Tackett, David Raciti, Nicholas Brady, Nicole Ritzert, and Thomas Moffat

An Inkjet Printed Flexible Electrocorticography (ECoG) Microelectrode Array on a Thin Parylene-C Film (2022)
Parylene-based flexible microelectrode patterns created by an inkjet printing technique could potentially find a myriad of applications in the field of neuroscience and brain-machine interfaces. | By Yoontae Kim, Stella Alimperti, Paul Choi, and Moses Noh 

Diagnosis and Management of Oral Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease (2021)
Review offers a systematic approach to diagnose and manage commonly encountered oral manifestations of pediatric inflammatory bowel diseases. | By Muhammad Ali Shazib, Kevin Byrd, and Ajay Gulati 

Blood Vessel-on-a-Chip Examines the Biomechanics of Microvasculature (2021)
Artificial blood vessel provides a methodology for investigating microvascular-related diseases. | By Paul Salipante, Steven Hudson, and Stella Alimperti

N-Acetyl Cysteine Modulates the Inflammatory and Oxidative Stress Responses of Rescued Growth-Arrested Dental Pulp Microtissues Exposed to TEGDMA in ECM (2020)
N-Acetyl cysteine is explored as a treatment for dental pulp whose growth has been arrested by toxic resin monomers in dental capping materials. | By Gili Kaufman and Drago Skrtic

Bone Microvasculature: Stimulus for Tissue Function and Regeneration (2020)
Researchers explain how a better understanding of vasculature controls on bone development and homeostasis on normal and disease cases will facilitate the development of novel disease treatments that promote bone regeneration and remodeling. | By Eun-Jin Lee, Mahim Jain, and Stella Alimperti

Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications (2020)
Current state-of-the-art research on insulator-based dielectrophoresis systems is reviewed, and potential future work is highlighted. | By Prateek Benhal, David Quashie, Yoontae Kim, and Jamel Ali 

Antibiotic Prescribing Habits and Preferences — a Survey of U.S. Dentists (2020)
Survey evaluates dentists’ habits and uses of antibiotics in treating endodontic infections. | By Rashad Vinh, Ana Bedran-Russo, Jamie Spomer, Olivia Urquhart, and Marcelo Araujo

pH-Responsive Release of Chlorhexidine (2020)
Researchers develop drug delivery systems that could be useful for the targeted treatment of bacteria or diseases that produce acid or generate local acidic environments. | By Xiaohong Wang, Han Byul Song, Vivek Prabhu, Yun Liu, and Jirun Sun

A Fluoride-Calcium-Phosphate Treatment Produced Persistent Reduction in Dentin Hydraulic Conductance (2020)
A new two-step treatment reduces dentin sensitivity. | By Laurence Chow, Antony Giuseppetti, and Shozo Takagi

Calcium Fluoride and Fluorapatite Formation in Fluoride-Calcium-Phosphate Complex Solutions (2020)
Results could assist in developing improved dentin desensitization and other remineralization treatments. | By Shozo Takagi, Eaman Karim, and Laurence Chow

U.S. Trends in Antibiotic Prescription by Dentists, 2002–2017 (2020)
Study finds that antibiotic prescribing by dentists has significantly declined in the past 15 years, although prescriptions for fewer than five days have increased since 2010. | By Cameron Estrich, Ruth Lipman, and Marcelo Araujo

Summary of the Evidence on the Safety, Efficacy, and Effectiveness of Human Papillomavirus Vaccines (2020)
Scientific research review of the evidence concludes HPV vaccines are safe, effective and efficacious. | By Alessandro Villa, Lauren Patton, Anna Giuliano, Cameron Estrich, Sarah Pahlke, Kelly O’Brien, Ruth Lipman, and Marcelo Araujo


The need for integrated research autopsies in the era of precision oral medicine. (2023)
Bruno Fernandes Matuck, Luiz Fernando Ferraz da Silva, Blake M. Warner, Kevin Matthew Byrd

Strategies for Developing Evidence-Based Clinical Practice Guidelines to Foster Implementation into Dental Practice (2022)
Article provides a brief overview of strategies that can be used to overcome common challenges to guideline adoption. | By Julie Frantsve-Hawley, Elliot Abt, Alonso Carrasco-Labra, Tim Dawson, Maria Michaels, Sarah Pahlke, Brad Rindal, Heiko Spallek, and Robert Weyant

Assuring the Safety of Dental Materials: The Usefulness and Application of Standards (2022)
Article covers the use of scientific research to establish specifications and standards used to evaluate dental materials and products, and how a practitioner can use these standards to ensure the safety and performance of the materials that they use in their everyday practice. | By Spiro Megremis

U.S. Dental Health Care Workers’ Mental Health during the COVID-19 Pandemic (2022)
Study assesses the prevalence of anxiety and depression symptoms among dental health care workers during the COVID-19 pandemic. | By Laura Eldridge, Cameron Estrich, JoAnn Gurenlian, Ann Battrell, Ann Lynch, Marko Vujicic, Rachel Morrissey, Stacey Dershewitz, Maria Geisinger, and Marcelo Araujo

COVID-19 and Scientific Illiteracy, a Syndemic (2021)
Commentary argues scientists must develop strategies for communicating clearly and concisely to refute misinformation and disinformation. | By Michael Glick, Mark Wolff, and Alonso Carrasco-Labra

How to Interpret and Use a Clinical Practice Guideline or Recommendation: Users’ Guides to the Medical Literature (2021)
A look at how clinicians must understand the implications of a guideline's recommendations, assess the trustworthiness of the guideline development process, and evaluate the extent to which the recommendations are applicable to patients in their practice settings. | By Romina Brignardello-Petersen, Alonso Carrasco-Labra, and Gordon Guyatt

Science and Research Influenced Health Policy during the COVID-19 Pandemic (2021)
ADASRI researchers argue that dental professionals' adherence to strict guidelines throughout the pandemic has paid off in current health policies that commend their efforts. | By Cameron Estrich and Marcelo Araujo

Machine Learning in Evidence Synthesis Research (2021)
Machine learning techniques are explored as a way to make the process of writing systematic reviews more efficient and less prone to error. | By Alonso Carrasco-Labra, Olivia Urquhart, and Heiko Spallek

How to Identify, Interpret, and Apply the Scientific Literature to Practice (2021)
Book chapter addresses how to formulate a clinical query to perform a thorough literature search and assess the trustworthiness and reliability of the available evidence to enhance patient care. | By Alonso Carrasco-Labra, Malavika Tampi, Olivia Urquhart, Scott Howell, Austin Booth, and Michael Glick

Teledentistry and mHealth for Promotion and Prevention of Oral Health: A Systematic Review and Meta-analysis (2021)
Evidence suggests that teledentistry, particularly mHealth (messages and apps), is a promising clinical tool for preventing and promoting oral health, especially under the accelerated virtualization of dentistry. | By Constanza Fernandez, C.A. Maturana, S.I. Coloma, Alonso Carrasco-Labra, and Rodrigo Giacaman

Employment Patterns of Dental Hygienists in the United States during the COVID-19 Pandemic (2021)
Study provides insights on dental hygienists’ employment patterns as well as their attitudes toward working as dental hygienists during a pandemic. | By JoAnn Gurenlian, Rachel Morrissey, Cameron Estrich, Ann Battrell, Sue Bessner, Ann Lynch, Matthew Mikkelsen, Marcelo Araujo, and Marko Vujicic  

Methods for Incorporating Nonrandomized Study Data for Policy-making (2020)
Researchers propose novel approaches to communicating harm outcomes for expert panels to consider when developing clinical practice guidelines. | By Lauren Pilcher, Malavika Tampi, Olivia Urquhart, and Alonso Carrasco-Labra

GRADE Evidence-to-Decision Framework for Developing Oral Health Policy (2020)
Framework harmonizes individual- and population-level perspectives for the development of oral health policies. | By Malavika Tampi, Olivia Urquhart, Lauren Pilcher, Sarah Pahlke, and Alonso Carrasco-Labra

Patients’ Values and Preferences in Dentistry: Current State, Next Steps (2020)
Researchers call for investments in well-conducted primary studies including patient-important oral health outcomes and perspectives. | By Sarah Pahlke, Malavika Tampi, Lyubov Lytvyn, Lauren Pilcher, Olivia Urquhart, and Alonso Carrasco-Labra

Policy and Guideline Development and Dissemination: The Role of Global Evidence Informing Local Policy and Clinical Decisions (2020)
By Alonso Carrasco-Labra

Preventive dentistry

The Effects of Staining and Cleaning on the Color and Light Transmittance Changes of a Copolyester Retainer Material with Different Surface Textures (2022)
The surface roughness of the retainer material plays a significant role in the ability of cleaning solutions to remove stains, demonstrating a greater effect on cleaning rough specimens with respect to improvements in light transmittance and greater changes in color. | By Laurie Susarchick, Insia Virji, Grace Viana, Mervat Mahmoud, Veerasathpurush Allareddy, Max Gruber, Henry Lukic, Spiro Megremis, and Phimon Atsawasuwan

Machine Learning in Predicting Tooth Loss: A Systematic Review and Risk of Bias Assessment (2022)
Computational solutions have a high accuracy in predicting tooth loss; however, they also display a high risk of bias. | By Akira Hasuike, Taito Watanabe, Shin Wakuda, Keisuke Kogure, Ryo Yanagiya, Kevin Byrd, and Shuichi Sato

A Roadmap for the Human Oral and Craniofacial Cell Atlas (2022)
Paper outlines directions for using single-cell and spatial multiomics approaches to create the first ever map of oral and craniofacial cells, which will lead to future innovations in the treatment of common and rare diseases. | By Ana Caetano, Ines Sequeira, and Kevin Byrd

Effect of Preradiation Dental Intervention on Incidence of Osteoradionecrosis in Patients with Head and Neck Cancer: A Systematic Review and Meta-analysis (2022)
Maintaining optimal oral health may help reduce the need for urgent preradiotherapy dental treatment, potentially reducing the risk of osteoradionecrosis of the jaw and minimizing delay of oncologic treatment in patients with head and neck cancer. | By Olivia Urquhart, Hillary DeLong, Kathleen Ziegler, Lauren Pilcher, Sarah Pahlke, Malavika Tampi, Kelly O’Brien, Lauren Patton, Nishant Agrawal, Theresa Hofstede, Deepak Kademani, Mark Lingen, Nathaniel Treister, C. Jillian Tsai, Alonso Carrasco-Labra, and Ruth Lipman

Effect of Heating on Physicochemical Property of Aerosols during Vaping (2022)
Study demonstrates that the heating conditions of the e-cigarette change the physicochemical properties of the aerosols and their metal contents, thereby possibly affecting users’ oral and respiratory systems. | By Taejun Ko and Shinae Kim

Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews (2021)
Fluorescence, visual or visual-tactile classification systems, imaging, transillumination and optical coherence tomography, and electrical conductance or impedance technologies are evaluated for their ability to detect and diagnose caries. | By Tanya Walsh, Richard Macey, David Ricketts, Alonso Carrasco Labra et al.

Novel Pit and Fissure Sealant Containing Nano-Calcium Fluoride and Dimethylaminohexadecyl Methacrylate with Double Benefits of Fluoride Release and Antibacterial Function (2020)
Novel sealant is promising to inhibit caries and promote the remineralization of enamel and dentin. | By Xiuzhi Fei, Yuncong Li, Michael Weir, Bashayer Baras, Haohao Wang, Suping Wang, Jirun Sun, Mary Melo, Jianping Ruan, and Hockin Xu

Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials (2020)
Applying protein repellents to restorations could help slow the formation of biofilm and associated oral diseases, researchers argue. | By Leopoldo Torres Jr. and Diane Bienek

Improving Caries Risk Prediction Modeling: A Call for Action (2020)
Researchers argue there is a need to improve the methodological standards and increase consistency in the way caries risk prediction models are developed and evaluated. | By Margherita Fontana, Alonso Carrasco-Labra, Heiko Spallek, George Eckert, and Barry Katz

Living Under a Cloud: Electronic Cigarettes and the Dental Patient (2020)
Researchers review the impact of e-cigarettes on oral health, dentistry's role in smoking cessation and the need to address gaps in vaping research. | By Purnima Kumar, Maria Geisinger, Hillary DeLong, Ruth Lipman, and Marcelo Araujo

Determination of Available Fluoride and Antimicrobial Activity of Charcoal-Containing Dentifrices (2020)
Study tests whether charcoal-containing fluoride dentifrices have at least 90% of the labeled amount of fluoride available and whether charcoal-containing dentifrices were effective against Streptococcus mutans. | By Christina Tyrakowski, Erin Claussen, Prerna Gopal, and Jamie Spomer

Development of Biofilm Model for Assessment of Oral Hygiene Products (2020)
Study describes the development of a clinically relevant antimicrobial susceptibility test for antiplaque and antigingivitis products by mimicking the oral environment. | By Erin Claussen, Prerna Gopal, and Jamie Spomer

Restorative dentistry

Survey of the mechanical and physical behaviors of yttria-stabilized zirconia from multiple dental laboratories. (2023) | By Yifeng Liao, Max Gruber, Henry Lukic, Jim McLees, Si Chen, Alan Boghosian, and Spiro Megremis

Direct materials for restoring caries lesions: Systematic review and meta-analysis—a report of the American Dental Association Council on Scientific Affairs (2023) | By Lauren Pilcher, Sarah Pahlke, Olivia Urquhart, Kelly K. O’Brien, Vineet Dhar, Margherita Fontana, Carlos González-Cabezas, Martha Ann Keels, Ana Karina Mascarenhas, Marcelle M. Nascimento, Jeffrey A. Platt, Gregory J. Sabino, Rebecca L. Slayton, Norman Tinanoff, Douglas A. Young, Domenick T. Zero, Malavika P. Tampi, DeVonna Purnell, Josefina Salazar, Spiro Megremis, Diane Bienek, and Alonso Carrasco-Labra 

Plain language summary for “Direct materials for restoring caries lesions: systematic review and meta-analysis—a report of the American Dental Association Council on Scientific Affairs (2023)" | By Lauren Pilcher, Sarah Pahlke, Olivia Urquhart, Kelly O’Brien, and Alonso Carraso-Labra

Impact of Curcumin Loading on the Physicochemical, Mechanical, and Antimicrobial Properties of a Methacrylate-Based Experimental Dental Resin (2022)
Blue light activation of a novel dental resin reduces presence of Streptococcus mutans. | By Patricia Comeau, Beatriz Panariello, Simone Duarte, and Adriana Manso

Novel Antibacterial Low-Shrinkage-Stress Resin-Based Cement (2022)
New cement may potentially enhance the longevity of fixed dental restoration through its excellent mechanical properties, low shrinkage stress, and strong antibacterial properties. | By Rashed Alsahafi, Xiaohong Wang, Heba Mitwalli, Abdullah Alhussein, Abdulrahman Balhaddad, Mary Anne Melo, Thomas Oates, Jirun Sun, H. K. Xu, and Michael Weir

Improve Dentin Bonding Performance Using a Hydrolytically Stable, Ether-Based Primer (2022)
Novel primer achieves improved dentin infiltration and bonding strength, suggesting significant potential for further developing dental restorative materials with extended service life. | By Xiaohong Wang and Shinobu Yamauchi

Electron Paramagnetic Resonance Characterization of Sodium- and Carbonate-Containing Hydroxyapatite Cement (2022)
Carbonate-containing hydroxyapatite synthesized via calcium phosphate cement proves to be a promising substrate for electron paramagnetic resonance-based dosimetry. | By Eaman Karim, Veronika Szalai, Lonnie Cumberland, Alline Myers, Shozo Takagi, Stanislav Frukhtbeyn, Ileana Pazos, and Laurence Chow

Effects of Thermal Cycling on Mechanical and Antibacterial Durability of Bioactive Low-Shrinkage-Stress Nanocomposite (2022)
Study develops an antibacterial, remineralizing, and low-shrinkage-stress composite. | By Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann Melo, Thomas Oates, Gary Hack, Christopher Lynch, Michael Weir, Jirun Sun, and Hockin Xu

Engineering 3-D Printed Scaffolds with Tunable Hydroxyapatite (2022)
Method may pave the way to engineer 3-D bone scaffolds with controlled hydroxyapatite composition and pre-defined properties, which will enhance graft-host integration in various anatomic locations. | By Yoontae Kim, Eun-Jin Lee, Anthony Kotula, Shozo Takagi, Laurence Chow, and Stella Alimperti

Repair Versus Replacement of Defective Direct Restorations: A Cross-Sectional Study among US Dentists (2021)
Of the 387 respondents, 83.7% stated that they repair defective restorations, and 16% stated that they always replace them. | By Wafaa Kattan, Olivia Urquhart, Carissa Comnick, Michelle McQuistan, Sandra Guzmán-Armstrong, Justine Kolker, and Erica Teixeira

Novel Low-Shrinkage-Stress Bioactive Nanocomposite with Anti-biofilm and Remineralization Capabilities to Inhibit Caries (2021)
Researchers develop a novel low-shrinkage-stress, antibacterial, and remineralizing resin composite to address dental composite restoration failure caused by recurrent caries at the margins. | By Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann Melo, Thomas Oates, Michael Weir, Jirun Sun, and Hockin Xu

Biopolymer Hydroxyapatite Composite Materials: Adding Fluorescence Lifetime Imaging Microscopy to the Characterization Toolkit (2021)
Fluorescence lifetime imaging microscopy is discussed for its potential to provide unique insights into the structure-property relationships of dental composites. | By Quinn Easter 

Kinetics of Solid–Liquid Interface Motion in Molecular Dynamics and Phase-Field Models: Crystallization of Chromium and Silicon (2021)
The hodograph equation proves sufficiently flexible for a reliable description of all nonlinearities of the kinetic curves predicted in molecular dynamics simulations of chromium and silicon. | By Eaman Karim, Miao He, Ahmed Salhoumi, Leonid Zhigilei, and Peter Galenko

Dental Amalgam Restorations in Nationally Representative Sample of US Population Aged ≥15 years: NHANES 2011–2016 (2021)
An objective and nationally representative rate of amalgam-restored caries for the US population is calculated for the first time. | By Cameron Estrich, Ruth Lipman, and Marcelo Araujo

Biofabrication of 3D Printed Hydroxyapatite Composite Scaffolds for Bone Regeneration (2021)
Proof-of-concept study opens venues in engineering high-resolution, implantable, and osteoconductive scaffolds with predetermined properties for bone regeneration. | By Yoontae Kim, Eun-Jin Lee, Albert Davydov, Stanislav Frukhtbeyen, Jonathan Seppala, Shozo Takagi, Laurence Chow, and Stella Alimperti 

Low-Shrinkage-Stress Nanocomposite: An Insight into Shrinkage Stress, Antibacterial, and Ion Release Properties (2021)
A novel bioactive nanocomposite was developed with low shrinkage stress, strong antibiofilm activity, and high levels of ion release for remineralization, without undermining the mechanical properties and degree of conversion. | By Ghalia Bhadila, Xiaohong Wang, Michael Weir, Mary Ann Melo, Frederico Martinho, Guadalupe Garcia Fay, Thomas Oates, Jirun Sun, and Hockin Xu

Light‐Activated Stress Relaxation, Toughness Improvement, and Photoinduced Reversal of Physical Aging in Glassy Polymer Networks (2020)
A covalent adaptable network with high glass transition temperature, superior mechanical properties including toughness and ductility, and unprecedented spatio‐temporally controlled dynamic behavior is prepared. | By Nancy Sowan, Han-Byul Song, Lewis Cox, James Patton, Benjamin Fairbanks, Yifu Ding, and Christopher Bowman 

Atomistic Simulation of the Generation of Vacancies in Rapid Crystallization of Metals (2020)
Simulations reveal that, for chromium and nickel, vacancy concentrations produced during crystallization can exceed the equilibrium values at corresponding temperatures by orders of magnitude. | By Miao He, Eaman Karim, Maxim Shugaev, and Leonid Zhigilei 

Novel Low-Shrinkage-Stress Nanocomposite with Remineralization and Antibacterial Abilities to Protect Marginal Enamel under Biofilm (2020)
New composite could inhibit recurrent caries at restoration margins by reducing polymerization stress and protecting enamel hardness. | By Ghalia Bhadila, Xiaohong Wang, Wen Zhou, Deepak Menon, Mary Ann Melo, Silvia Montaner, Thomas Oates, Michael Weir, Jirun Sun, and Hockin Xu

Bioactive Low-Shrinkage-Stress Nanocomposite Suppresses S. mutans Biofilm and Preserves Tooth Dentin Hardness (2020)
New bioactive nanocomposite has the potential to suppress recurrent caries at restoration margins, protect tooth structures and increase restoration longevity. | By Ghalia Bhadila, Hanan Filemban, Xiaohong Wang, Mary Ann Melo, Dwayne Arola, Franklin Tay, Thomas Oates, Michael Weir, Jirun Sun, and Hockin Xu

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease (2020)
Novel sensors can send early warning signals before an implant fails. | By Jeffrey Kim, Gery Stafford, Carlos Beauchamp, and Shinae Kim

The Self-Renewal Dental Pulp Stem Cell Microtissues Challenged by a Toxic Dental Monomer (2020)
Study determines the impact of triethyleneglycol dimethacrylate on the ability of dental pulp stem cells to maintain their self-renewal capabilities, develop and preserve their 3-D structures and deposit tertiary dentin. | By Gili Kaufman, Naima Makena Kiburi, and Drago Skrtic 

Fracture Toughness of Zirconia with a Nanometer Size Notch Fabricated Using Focused Ion Beam Milling (2020)
Study proposes an alternative solution to help the dental community examine and comprehend fracture behaviors of zirconia dental ceramics used to restore damaged teeth. | By Yifeng Liao, Max Gruber, Henry Lukic, Si Chen, and Spiro Megremis

Antimicrobial, Biocompatibility and Physicochemical Properties of Novel Adhesive Methacrylate Dental Monomers (2020)
Study evaluates novel antimicrobial copolymers to help yield dental restoratives with well-controlled biofunction. | By Diane Bienek, Anthony Giuseppetti, Ugochukwu Okeke, Stanislav Frukhtbeyn, Peter Dupree, Sharukh Khajotia, Fernando Esteban Florez, Rochelle Hiers, and Drago Skrtic

3D Printing of Composition-Controlled Copolymers (2020)
A computer-controlled method may be used for making dental devices for dental restorative material, denture, orthodontic treatment, dental implant, implant, tissue regeneration, and tissue engineering. | By Jirun Sun and Young Lee

EPR Properties of Carbonated Hydroxyapatite (CHA) Synthesized through Calcium Phosphate Cements (2020)
Researchers argue CHA cements could be used as electron paramagnetic resonance (EPR) calibration references and dosimeters. | By Eaman Karim, Lonnie Cumberland, Shozo Takagi, Stanislav Frukhtbeyn, Ileana Pazos, and Laurence Chow 

Physical and Thermal Behavior of "Clear" Plastic Orthodontic Materials (2020)
Study measures the physical and thermal behavior of four commercially available orthodontic materials. | By Henry Lukic, Raquel Miera, and Spiro Megremis

Stimuli-Responsive Azo-QPS-Containing Methacrylate Monomers/Polymers (2020)
Lab-made monomers and polymers capable of switching physicochemical properties in response to pH variations in oral environments could become a new class of dental restoratives. | By Han Byul Song, Xiaohong Wang, Sara Orski, Kathryn Beers, and Jirun Sun

Physicochemical, Mechanical, and Antimicrobial Evaluation of Novel Bioactive Resin (2020)
New antimicrobial monomers are expected to yield a new class of restoratives with both antimicrobial and remineralizing capabilities. | By Diane Bienek, Anthony Giuseppetti, Stanislav Frukhtbeyn, and Drago Skrtic

Minimize Polymerization Stress Using a pH-Sensitive Compound (2020)
A pH-sensitive quaternary pyridinium salt could minimize tooth fracture and microleakage in dental restorations. | By Jirun Sun, Ethan Finley, and Xiaohong Wang

Novel Antimicrobial Monomers Increase Shear Bond Strength of Dental Restoration (2020)
Novel methacrylate analogs of antimicrobial quaternary ammonium salts functionalized with carboxylic groups increased the shear bond strength of dental restorations and exhibited satisfactory biocompatibility. | By Anthony Giuseppetti, Peter Dupree, Stanislav Frukhtbeyn, Leopoldo Torres, and Diane Bienek

Dentin Biomodification Induced by Proanthocyanidins from Rhodiola rosea (2020)
The flower enhances resin adhesion to dentin. | By Ariene Leme-Kraus, Mariana Cavalcante Dos Reis, Bin Zhou, Yvette Alania, Shao-Nong Chen, Guido Pauli, and Ana Bedran-Russo

Protecting Pulp by Restoring Reparative Cellular Function in ECM Culture (2020)
Study authenticates the dental pulp / extracellular matrix platform as an efficient tool for validating the impact of molecules to restore mineral deposition in compromised tissue and maintain reparative dentin formation. | By Gili Kaufman, Anthony Kotula, William Jones, and Fjorela Xhyliu

Novel Bioactive Composite Materials for Dental and Bone Restorations (2020)
Novel material exhibits anti-inflammatory, anti-microbial and osteogenic properties needed for the next generation of dental and bone restoration. | By Stanislav Frukhtbeyn, Michael Valerio, Jeffrey Kim, and Gili Kaufman

Fracture-Toughness of Zirconia with Nanometer-Sized Notches Fabricated Using Focused-Ion-Beam Milling (2020)
Study investigates an alternative method for measuring the mechanical performance of zirconia dental ceramics. | By Yifeng Liao, Max Gruber, Henry Lukic, and Spiro Megremis

Study of 3Y-TZP Degradation via Accelerated Hydrothermal Aging (2020)
Researchers determine the kinetics of tetragonal-to-monoclinic transformation in 3Y-TZP powder via hydrothermal treatment. | By Max Gruber, Yifeng Liao, and Spiro Megremis

High-Performance Dental Adhesives Containing an Ether-Based Monomer (2020)
Novel adhesives demonstrate potential in developing dental restorations with extended service life and may find wider dental applications and broader utility in medical device development. | By Shinobu Yamauchi, Xiaohong Wang, Hiroshi Egusa, and Jirun Sun