According to the World Health Organization (WHO), oral diseases affect nearly 3.5 billion people worldwide. The hard and soft tissue surfaces of the oral cavity provide the ideal environment for abundant microbial growth and biofilm formation (dental plaque), which can lead to caries formation. Furthermore, dental resin composites are prone to failure due to stress and exposure to the oral environment, leading to the formation of secondary caries. Antimicrobial mouthwashes and toothpastes exist for plaque control, and antimicrobial additives may be used in dental resins. However, problems with existing antimicrobial materials include non-selective behavior that may adversely affect the oral microbiome, and questionable long-term effectiveness.