Clinical Practice Guidelines and Dental Evidence

Our collection of evidence-informed clinical practice guidelines that will help you improve your practice.
Oral Cancer Guideline (2026 Update)

These updated recommendations guide the use of cytology and vital staining adjuncts for early oral cancer detection in an interactive format.

Vital staining

Clinical and Public Health Guidelines

The strongest resources to aid oral health professionals in clinical decision-making. Developed by a guideline panel, clinical and health guidelines critically appraise, summarize, and interpret relevant evidence to formulate recommendations that can be applied to patient care. Explore current clinical and health guidelines below.

Oral cancer guideline (2026 Update)

These updated recommendations guide the use of different adjuncts for early oral cancer detection in an interactive format.

Patient selection X-ray recommendations

Addresses both 2-D and 3-D imaging, featuring clinical scenarios.

Optimizing radiation safety

Addresses appropriate use of dental X-rays and discontinuation of lead aprons, thyroid collars.

Pain management

Recommendations for managing acute dental pain in children, adolescents and adults after tooth extraction(s) or for the temporary management of toothache.

Restorative caries treatments

Recommendations for the use of 16 restorative caries treatments – which direct restorative materials and caries removal approaches to use.

Nonrestorative caries treatments

Clinical recommendations for the use of nine nonrestorative caries treatments, including the ADA's first-ever recommendations for silver diamine fluoride (SDF).

Antibiotics for dental pain and swelling

The latest recommendations for antibiotic usage in the urgent management of pulpal- and periapical-related dental pain and intra-oral swelling.

Antibiotics to prevent infective endocarditis

Recommendations from the American Heart Association on the use of antibiotics to prevent infective endocarditis.

Antibiotics to prevent prosthetic joint infection

Recommendations for the use of antibiotic prophylaxis to prevent orthopaedic implant infection in dental patients.

Fluoride toothpaste for young children

Guideline recommending a unified message to the general public regarding fluoride toothpaste usage for children under six years of age.

Non-fluoride caries prevention agents

Clinical recommendations for the use of agents such as sucrose-free polyol chewing gums, xylitol dentifrices, and chlorhexidine in preventing caries.

Periodontitis treatment

ADA panel recommendations for nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts.

Sealants for caries prevention

Expert panel recommendations for the use of pit-and-fissure sealants to prevent caries.

Topical fluoride for caries prevention

ADA panel recommendations for various topical fluoride agents for caries prevention, including mouth rinses, varnishes, gels, foams and pastes.

Education

Want to learn how to incorporate the latest scientific evidence into clinical practice? Check out these brief educational videos that demonstrate the techniques and principles of evidence-based dentistry.

How-to videos

Explore various instructional videos that help illustrate certain evidence-based dentistry techniques and clinical procedures.

A photograph of a person’s hands typing on a laptop computer.

Evidence-Based Dentistry

ADA Policy Statement on Evidence-Based Dentistry: The ADA defines the term evidence-based dentistry as an approach to oral health care that requires the judicious integration of systematic assessments of clinically relevant scientific evidence, relating to the patient’s oral and medical condition and history, with the dentist’s clinical expertise and the patient’s treatment needs and preferences.